STING agonist-4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

STING agonist-4 是干扰素基因 (STING) 受体刺激剂的激动剂 (IC50: 20 nM)。

STING agonist-4 is an agonist of stimulator of Interferon Genes (STING) receptor (IC50: 20 nM).(In Vitro):STING agonist-4 (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (0.001 nM-1 μM) inhibits the binding of full-length STING to the solid support (Kd: 1.6 nM). STING agonist-4 (0-100 μM) is 18-fold more potent than cGAMP (an endogenous STING ligand)(EC50 of 53.9 μM). STING agonist-4 (3 μM; 4 hours) promotes the production of interferon γ-induced protein 10 (IP-10), IL-6, and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.

STING agonist-4 (Compound 2) (0.3-30 μM; 2 hours) causes phosphorylation of IRF3 and STING that is inhibited by the TBK1 inhibitor BX795 and induces dose-dependent secretion of IFN-β with an EC50 of 3.1 μM. STING agonist-4 (Compound 2) (0.001 nM-1 μM) inhibits binding of full-length STING to the solid support with an apparent dissociation constant (Kd) of approximately 1.6 nM.STING agonist-4 (Compound 2) (0-100μM) is 18-fold more potent than cGAMP (an endogenous STING ligand), with an EC50 of 53.9 μM. STING agonist-4 (Compound 2) (3 μM; 4 hours) promotes production of interferon γ-induced protein 10 (IP-10), IL-6 and TNF-α by a mechanism that is dependent on STING-mediated activation of TBK1.Cell Viability Assay Cell Line:Human peripheral blood mononuclear cells (PBMCs) Concentration:0.3 μM, 1 μM, 3 μM, 10 μM and 30 μM Incubation Time:2 hours Result:Causedphosphorylation of IRF3 and STING and induced secretion of IFN-β.

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Immunology/Inflammation

STING

acetolactate synthase (ALS)

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2138300-40-8

678.758

C34H38N12O4

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (14.73 mM)

CCn1nc(C)cc1C(=O)Nc1nc2cc(ccc2n1CCCCn1c(NC(=O)c2cc(C)nn2CC)nc2cc(ccc12)C(N)=O)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years